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GEP44 mediates insulin-independent glucose uptake in muscle via interactions with Y1-R GEP44 may also reduce serum glucose levels via direct interactions resulting in increased glucose uptake in muscle tissue

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Resveratrol inhibits TNF--induced IL-1, MMP-3 production in human rheumatoid arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway